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  Tuesday, 08/12/08
Posted 08/13/08,  10:37 am ET

(Scroll down to see Jim's comments below)

 
 
Today's date:  Tuesday, 08/12/08

  Dow Jones: 11,642   - 139
  NASDAQ:   2,430   -    9
  S&P 500:   1,289   -  15
 
 
 
 
 
First Segment
   
Opening Segment 1 Title: 'Don't Fall Behind'

.  .  .  .  .

Featured Stock(s):

Genzyme Corp. (GENZ)

See GENZ's official investor relations' site here.
See the Yahoo! Finance profile for GENZ here.

See Opening Segment 2, below...

 
After this segment, you can see Jim's Lightning Round picks here...

.  .  .  .  .

JJC:    Ugliness came back with abundance today... banks, brokers, rails... they all got crushed as the oils, at last, seemed to find their footing... and the natural gas stocks - the worst hit group, other than banks - actually rallied...

What's happening?...

I believe that oil and natural gas have finally come down to a level where there might be some demand...  Gasoline, I told you $3.50...  that's where people pump.  $110 oil... our original price target, give or take a buck or two... and the cleaner carbon natural gas... it's trading at $8.  Coal's worth $7.50.  They're at parody...

Meanwhile, the banks... they're back on the red-hot griddle... as, suddenly, the analysts community has turned on them big, citing weaker earnings, bad equities markets... the usual negatives... 

And most importantly though, we are back where the SEC is allowing the kind of free-fire zone short sell that we can condemn on this show.  The rules that ban bear raids are once again gone...  What?  Do you think these stocks went down for no reason?  The rules are gone.  They are the rules that stop endless, motivated declines by short sellers... who take your stocks and slam them in your face, using rules that should be enforced... and other rules that they just threw away that could really stop this.  The SEC and its academic bedfellows are out and doing it again... 

Here's a memo, SEC...  Have me come down... I'll explain to you the way the world really works... how the hedge funds drive these stocks down, now with your complicity... and you can explain to me your position, which allows banks to get raided and, ultimately, run into the ground, perhaps with bank runs...  by hedge funds needing to make oodles of money by rich clients...  Shame on you, SEC...   

.  .  .  .  .

My take is that you can take an oil or bank... if you don't own either... and begin the process of buying, into tomorrow's raiding.  They're going to raid them all week and, believe me, they will raid them... 

Oh, by the way, the rails... totally raided today... I think they're going to crush them.  You've got to leave that group... you've got to leave them.  It's one of my favorite groups, but let the hedge funds do their damage.  They decided to operate on the rails.  They're going to take them down...

.  .  .  .  .

Now let's play some offense...

For us on Mad Money, well, we're playing offense by playing biotech...  You've heard of "Shark Week"... this is "Biotech Week"...

Biotech was the best-performing group in 1990...  It was led by Amgen Inc. (AMGN)...  It's also generally beloved by the democratic party, even as they hate big pharma, and they seem to be poised to win big this December...

There have been takeovers galore in the group, the biggest being Roche's bid for 45% of Genentech Inc. (DNA)... 

And, finally, for everything there is a season...  and, for biotech, that season's usually the fall... because it tends to be loaded with medical conferences and drug approvals... a lot of news coming...

Hey, why does this matter?...  Because, in this wild market, where people are shooting at you from left to right, and it's anything but (easy), you need to be grounded in something in the future... grounded from lightning strikes... and you'll know you'll hold on when the stocks go down, and you won't panic... 
 

.  .  .  .  .

So we're looking for biotech stocks that fit somewhere in this template, and the one I've got today is... Genzyme Corp. (GENZ). 

While the democrats generally love biotech, they absolutely adore biotechs like GENZ, that focus on developing drugs that treat rare diseases with small constituencies.

GENZ makes drugs that fall into what's called "orphan" status... meaning that they treat diseases that affect less (fewer) than 200,000 people in America, or in the EU (European Union of countries)... diseases that occur in less (fewer) than 5 in every 10,000 people.

If you make orphan drugs in America, you get seven years of exclusivity, which is really just another word for no competition...  We still love a government for, by and of the corporation... in addition to tax credits for R&D (research and development)...  great, great, great...  and just imagine how those tax credits could balloon if Obama wins...  It still looks like he's going to, although the defense stocks (which would respond better to a McCain win) are saying it's getting even.

The EU gives orphan drugs 10 years of exclusivity.  They may be orphan drugs but, to me, they could make you Daddy Warbucks...

About 51% of GENZ's sales come from drugs that treat Lysosomal storage disorders...  They're a group of rare genetic disorders where a patient lacks an enzyme that allows their cells to function normally.  There are over 40 different kinds of these disorders, and they go by really difficult names... things like Gaucher disease, Fabry disease and Pompe disease, the big three Genzyme treats...

Even though not many people have these diseases, GENZ still makes a lot of money selling the drugs, because they can charge the exorbitant prices...

For example, GENZ's biggest drug is called Cerezyme...  It's for Type 1 Gaucher disease, which is an enzyme deficiency that causes fatty material to collect in the spleen, the liver, the kidneys, the lungs... brain and bone marrow.  This was a $1.1 billion drug in 2007, even though less than 5,000 people take it, because the annual cost of Cerezyme is $250,000...

The New York Times may not think this is worth it, but the patients do, and that's what matters...
 

.  .  .  .  .

Cerezyme's manufacturing patents expire in 2010 here and 2013 in the EU, but GENZ's got plenty more drugs that still have exclusivity... it is a beautiful pipeline...

It's got Fabrazyme for Fabry disease... that causes lesions and burning pain in the extremities...  The stuff that they cure is so awful.  This is an amazing company.  It causes kidney failure if not attended to...

GENZ has U.S. exclusivity here until 2010.  Last year, it was a $424 million drug, but the number of people who take it is expected to grow 18% this year, 12% next year...

GENZ has so many of these orphan drugs...  It's got Myozyme for Pompe disease.  That's a metabolic disorder where the patient doesn't have the enzyme needed to break down sugar for energy...  patent-protected through 2013...

Aldurazyme for another metabolic disorder... it has exclusivity until 2010... although GENZ pays BioMarin Pharmaceutical Inc. (BMRN) royalties for this one...  BMRN has come right back down.  I've got to do some work on that...  

It's expected to grow to a $1.1 billion franchise and all of these drugs cost between $220,00 and $300,000 a year on average for just a single patient, and yet, they've got to pay.

Those are just the orphan drugs. 

GENZ's got a great kidney franchise, which management expects to generate $1 billion in sales by 2010. 

.  .  .  .  .

Then there's the pipeline...

I mean, I could see a traditional pharma company buying GENZ just for what it's got in the late-stage pipeline, although they should have bought it years ago, it's been such a winner...

There's Mozobil, a stem cell transplant drug that could be worth $150-250 million.  The FDA will decide in the third quarter whether to fast track that one.

How about Mipomersen (yes, we had to look up these names on the Genzyme website pipeline chart) for familial high cholesterol.  This one's in Phase III studies.  $450 million... maybe $900 million... a catalyst coming in the form of four trials GENZ's doing in collaboration with Isis, sometime during the second half of the year...

How about the biggest kicker of all?...  A drug called Alemtuzumab... this is for Multiple Sclerosis, and it's already in Phase III.  It could be years away... the last phase of studies before the FDA approves or rejects the drug.  Look, I don't even know how big this one is, but the global market for MS treatment is over $6 billion...     

.  .  .  .  .

I think GENZ has what you want from a biotech...

...extraordinarily expensive drugs, with exclusive orphan protection... democrats endorse that... along with what appears to be a fabulous pipeline.

I don't know...  how about $92 instead of $78?... 

Remember, biotech works.  A $78 stock I think goes to $92... that's if nobody decides to buy it for a takeover...

.  .  .  .  .

The Bottom Line!:     I believe the time is still right for biotech, particularly when the banks go down... biotech tends to go up the next day.  I think Genzyme Corp. (GENZ), with its orphan drugs, is going to be a big winner, come November.  The democrats love this kind of company, as much as they hate big pharma.  I think GENZ... yesterday, we did another biotech stock.  You know we're going to stay on biotech all week.  These are the winners.

 

   
 

Stock Snapshots - Includes all stocks mentioned above

 

 

Jim
Cramer's
rating on
this stock

STOCK
SYMBOL

Closing
price
that
day

Opening
price
next
day

Full Company Name/Comments
(see comments above for each)


GENZ

79.53

na

Genzyme Corp. (GENZ)


     

 

 



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